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In recent years, nucleic acid drugs have become the key areas of global R&D and investment. Compared with traditional drugs for disease intervention at the protein level, nucleic acid drugs can play a role in the source of genetic information transmission, so they have the advantages of strong specificity, rich gene targets, lasting curative effect, etc., and avoid the complicated synthesis and purification process of traditional drugs, which can significantly reduce production costs.

Since the discovery of DNA double helix structure in 1953, nucleic acid drugs have developed for 70 years, including antisense nucleic acid (ASO), small interfering RNA(siRNA), microRNA (mirna), small activating RNA(saRNA), messenger RNA(mRNA), aptamer, ribozyme, antibody nucleic acid-coupled drugs (RNA). Except for mRNA drugs, basically all other nucleic acid drugs are composed of single-stranded or double-stranded ribonucleotides or deoxynucleotide, so they are also called oligonucleotide or small nucleic acid drugs.

Different from the protein encoded by mRNA drugs, oligonucleotide drugs mainly pair with DNA, mRNA or pre-mRNA through the principle of base complementary pairing, and regulate gene expression through a series of mechanisms such as gene silencing, non-coding RNA inhibition and gene activation.

Time axis of nucleic acid drug development Source: Guosen Securities

At present, there are 17 kinds of nucleic acid drugs listed in the world, and three kinds of them have applied for listing. There are 32 kinds, 115 kinds and 113 kinds of pipelines under research in Phase III, Phase II and Phase I respectively. Among 719 kinds of nucleic acid drugs in the world, ASO has the most varieties (253 kinds), and the rest are siRNA(229 kinds) and mRNA(72 kinds). TOP5, the leading companies in the global investment and distribution of nucleic acid drugs, are Ionis(91 models), Alnylam(34 models), simaomics(25 models), arrowhead (24 models) and AstraZeneca (18 models).

Sources of 17 nucleic acid drugs listed in the world: insights database

Because most of the nucleic acid drugs are oligonucleotides, oligonucleotides become important raw materials of nucleic acid drugs, and oligonucleotides are composed of dozens to dozens of nucleotides in series, so nucleoside monomers are also the key raw materials of nucleic acid drugs.

According to QYR’s forecast, in 2021, the global nucleotide market (including oligonucleotides and monomers) sales will be US$ 510 million, and China is the largest global nucleotide production market, accounting for about 55%. At present, the domestic market size of raw materials for nucleic acid drugs is estimated to be 280 million US dollars. In addition, the global demand for nucleotides is about 50,000 tons, and the annual output value of the domestic nucleotide market is about 27,500 tons. Most of them are exported to foreign countries, and the internal digestion ability used in the production of nucleic acid drugs in China is weak. Compared with the production of nucleic acid drugs in China, there is still a big gap abroad, which is not unrelated.

Because in general, 90% of the global nucleotides are used for the production of nucleic acid drugs, and only about 10% are used in health food, agriculture and other fields.

From the production process of oligonucleotide raw materials, the mainstream method for synthesizing oligonucleotides in the upstream process is the solid-phase phosphoramidite triester method, in which phosphoramidite monomer and solid-phase carrier are deprotected, coupled, oxidized, capped and other steps in a nucleic acid synthesizer to obtain the target base sequence, that is, the crude oligonucleotide, and then the crude oligonucleotide is deprotected and cut off from the solid-phase carrier, and the purity of the crude oligonucleotide is preliminarily detected by liquid chromatography, followed by purification, ultrafiltration, freeze-drying and other steps.

Taking DNA primer synthesis as an example, the following figure shows the steps of solid-phase phosphoryl synthesis. In the purification process, there are mainly reverse-phase chromatography (solid-phase synthesis-reverse-phase chromatography purification-demethylation-ethanol precipitation method-freeze-drying), ion-exchange chromatography (solid-phase synthesis-ion-exchange chromatography-concentration/deep filtration-freeze-drying) and hydrophobic chromatography combined with ion-exchange chromatography (solid-phase synthesis-hydrophobic chromatography-demethylation-ion exchange-UF/DF-API solution. In addition to the above chemical synthesis methods, other methods for preparing nucleotides include RNA enzymatic hydrolysis, microbial fermentation and biocatalysis.

Figure. Synthesis of primers by solid-phase phosphoryl method Source: Internet public information.

Oligonucleotides and nucleoside monomers are the key materials of nucleic acid APIs, and qualified suppliers that meet the quality requirements are rare all over the world. This is mainly due to the use of solid-phase synthesis technology in the production of nucleic acid APIs, which has high barriers in process development, process amplification and quality control, and the initial investment in solid-phase synthesis equipment and clean environment of nucleic acid APIs is very large, and the production needs to meet the international GMP requirements.

TOP10 giants, one of the few established qualified suppliers in the world, are Danaher Corporation (established in 1969), Merck KGAA (established in 1668), Eurofins Scientific SE (established in 1987) and Thermo Fisher Scientific Inc. (established in 2006). Agilent Technologies, Inc. (established in 1999), GE Healthcare (established in 1994), Kaneka Eurogentec S.A. (established in 1985), Gene Design, Inc. (established in 2000), LGC Bio Search Technologies (established in 1993), Bio-Synthesis Inc. (established in 1984)

There are about 160 suppliers of nucleotide raw materials in China, and their regional distribution is relatively scattered, including 43 enterprises in Shaanxi, 22 in Jiangsu, 21 in Hubei, 21 in Hubei, 20 in Shandong, 16 in Guangdong, 11 in Anhui, 6 in Zhejiang, 6 in Shanghai, 5 in Henan, 5 in Hunan, 3 in Tianjin and 2 in Shanxi.

Representatives of domestic oligonucleotide manufacturers are Guangzhou Ruibo, Hequan Pharmaceutical and Shanghai Zhaowei.

Guangzhou ruibo

Guangzhou Ruibo is a well-known CDMO company of oligonucleotide APIs in China. In 2013, it took the lead in establishing a large-scale oligonucleotide cGMP manufacturing workshop in China. In 2016, it obtained the license of oligonucleotide APIs production issued by CFDA, and it is also the only local enterprise that has obtained the license so far. In 2018, the construction of cGMP production base for oligonucleotide was completed, with an area of over 20,000 square meters, including 2,700 square meters of production workshop and 2,500 square meters of aseptic filling and finished product workshop. In mid-2019, a single batch of 1.8mol synthesis workshop with a purification capacity of 4,000L/h and a freeze-drying workshop of 1kg to 40kg can meet the commercial production demand of oligonucleotide APIs above the kilogram level.

Hequan pharmacy

In 2020, Hequan Pharmaceutical announced that its kilogram-level production workshop of oligonucleotide raw materials was officially put into operation, with an area of 2,800 square meters. Its oligonucleotide platform can support various types of oligonucleotide products, such as deoxyribonucleic acid (DNA), ribonucleic acid (RNA), morpholino antisense oligonucleotide (PMO) and polypeptide conjugated morpholino antisense oligonucleotide (PPMO). In July this year, another brand-new oligonucleotide and polypeptide production building of Hequan Pharmaceutical, located in Changzhou API R&D and production base, was also put into operation, including an oligonucleotide production workshop with an area of 2,840 square meters. After putting into production, Hequan Pharmaceutical will have four large-scale oligonucleotide production lines of kilogram class and more than 20 small-scale and medium-scale production lines, and the maximum total scale of single oligonucleotide synthesis will increase from 1.9mol to 6.0mol.

Zhaowei biology

Zhaowei Bio was established in 2001. It is one of the earlier enterprises in China engaged in R&D and production of nucleosides and modified nucleosides, and passed the ISO9000 quality management system certification in 2008. The company focuses on the field of nucleoside and nucleotide products, producing and selling various series of products such as modified nucleoside, nucleotide, phosphoramidite gene monomer, targeted tracer and biological enzyme. Zhaowei Bio, as a global large-scale manufacturer of oligonucleotides and gene monomers, can reach 7 billion doses of mRNA for nucleic acid vaccines at present, with a total output value of 1.5 billion in 2021. In July 2022, Zhaowei Bio invested 2.5 billion yuan in the research and development and production base of small nucleic acid drugs and settled in Hangzhou Bay, Shanghai.

From a global perspective, the overall supply of nucleotide raw materials is in short supply, and it still belongs to the global shortage of products. With the gradual release of clinical potential of nucleic acid drugs in the future, the related raw materials will be driven to continue to grow in the future, and the future prospect is good. As a domestic enterprise, we should focus on solving the technical research and development of innovative nucleic acid drugs, increase the ability of self-production and self-marketing, and grow into a leading nucleic acid drug enterprise on a par with international giants as soon as possible.

　　Cctv newsOn the morning of September 20th, the State Council Press Office held a routine briefing on the State Council policy to interpret the economic situation and policies and answer questions from reporters.

　　Tao Qing, director of the Operation Monitoring Coordination Bureau of the Ministry of Industry and Information Technology, said that since the beginning of this year, the Ministry of Industry and Information Technology has resolutely implemented the decision-making arrangements of the CPC Central Committee and the State Council, actively responded to various risk challenges, and made efforts to stabilize growth, improve quality and optimize structure. In August, industrial production resumed steadily, and enterprise benefits gradually improved.

　　First, industrial production has steadily picked up. In August, the added value of China’s industrial enterprises above designated size increased by 4.5% year-on-year, and the growth rate was 0.8 percentage points higher than that of the previous month. From the perspective of industry, from January to August, the added value of 27 of the 41 major industrial sectors increased year-on-year. Among the top 10 manufacturing industries accounting for GDP, the growth rate of seven industries is higher than the national average, and the contribution rate of the top 10 industries to the overall industrial growth reaches 87.4%. From a regional perspective, from January to August, among the top 15 provinces in terms of industrial added value, the growth rate of 9 provinces was further accelerated compared with the first half of the year.

　　Second, the industrial structure has been continuously optimized. Investment in high-tech manufacturing industry has accelerated. From January to August, manufacturing investment increased by 5.9% year-on-year. Among them, investment in high-tech manufacturing increased by 11.2% year-on-year. The equipment manufacturing industry has developed rapidly. In August, the added value of the equipment manufacturing industry increased by 5.4% year-on-year, contributing 38.9% to the total industrial growth. New products grew rapidly. In August, the output of service robots and civil aircraft increased by 73.7% and 33.3% respectively. The output of photovoltaic cells, lithium-ion power batteries for automobiles and other products also increased by 77.8% and 31.5% respectively.

　　Third, the positive factors of steady industrial growth are accumulating. The connection between production and marketing of enterprises has been further smoothed. The producer price index (PPI) of industrial producers continued to narrow, and the decline in August was further narrowed by 1.4 percentage points compared with the previous month. The sales rate of products of industrial enterprises above designated size was 97.4%, which has been restored to above 97% for two consecutive months. The decline in corporate profits has also further narrowed. In the first seven months, the profits of industrial enterprises above designated size decreased by 15.5% year-on-year, but the decline has been continuously narrowed. With the decline of upstream raw material prices, corporate revenue is improving, and the cost pressure of enterprises has eased. Corporate confidence is also gradually increasing. In August, the manufacturing PMI further rebounded. Among them, the production index and the new order index were 51.9% and 50.2%, respectively, both of which were high points in five months.

　　In the next step, together with all regions and departments, we will resolutely implement the decision-making arrangements of the CPC Central Committee and the State Council, and promote the industrial economy to achieve effective upgrading in quality and reasonable growth in quantity.

　　The first is to strengthen the coordinated implementation of policies. We will step up the implementation of the work plan for the steady growth of ten key industries and promote the steady growth policy to achieve results.

　　The second is to accelerate the recovery and expansion of demand. Strengthen quality brand building, promote supply-side innovation, and create demand with high-quality supply. Guide enterprises to expand the international market according to local conditions and further tap the export potential.

　　The third is to step up efforts to enhance development momentum. Deeply implement intelligent manufacturing engineering and accelerate the transformation and upgrading of traditional industries. The system will promote the development of emerging industries such as 5G, intelligent networked cars and new materials, open up new fields and new tracks, cultivate a number of new engines for growth and create new competitive advantages.

A few days ago, the new Lectra 08 EM-P will be officially launched on August 8. Compared with the current models on sale, the new Lectra 08 EM-P is expected to be adjusted in terms of configuration, such as changing the visor of the Lectra 07 EM-P, the sunflower central control panel, and increasing the power supply of the trunk.

The current LECK 08 EM-P was launched in September last year, and a long-life plus model was launched in April this year. At present, there are five models on sale, and the official guide price is 195,800-258,800 yuan. Its body size is 4820mm long, 1915mm wide, 1685mm high and the wheelbase is 2848mm. It adopts a 12.3-inch full LCD instrument panel and a 15.4-inch floating central control panel, and is equipped with two "Longying No.1" chips with 7nm technology.

In terms of power, the current LECK 08 EM-P adopts the EM-P super extended-range electric scheme, and is equipped with Contemporary Amperex Technology Co., Limited 21.2kwh battery pack, with two-wheel drive and four-wheel drive versions. The two-drive version consists of a 1.5T four-cylinder special-purpose electric hybrid engine and a front drive motor. The maximum power of the engine is 115kW, and the maximum power of the motor is 160kW. The four-wheel drive version consists of a 1.5T four-cylinder electric hybrid engine and three drive motors, with a combined maximum power of 436kW and a system peak torque of 905nm.

The calendar in 2024 slowly turned to the last page, and the year-end sprint of the automobile market began. At this critical time, Tesla ModelY has become the center of the auto market with its unique charm and preferential measures. Today, let’s explore it together and see what’s different about this eye-catching model. And how its preferential policies at the end of the year caused waves in the auto market.

The first thing I have to mention is the sales myth of Tesla ModelY.

The cumulative sales volume from January to October this year has reached 373,000 units, which is not only impressive, but also makes ModelY sit firmly on the sales throne in the SUV market.

Tesla’s record does not rely on price wars, but on its excellent product strength and high recognition in the market.

The starting price of ModelY is over 200,000, but it can achieve such results in the extremely competitive market, which fully reflects the high recognition of consumers.

However, when ModelY’s sales showed a particularly strong development trend, Tesla unexpectedly launched preferential activities.

From November 25th to December 31st, the final payment of ModelY rear-wheel drive and long-life all-wheel drive models will be reduced by 10,000 yuan, with the price starting from 239,900 yuan, and interest-free financial loan service will be provided for an additional five years.

This policy undoubtedly adds another fire to ModelY’s hot sales and makes the already hot models more attractive.

However, the question has arisen. Is there a small idea of Tesla hidden in this preferential policy? According to market analysis, the purpose of Tesla’s move is to clean up the existing inventory and make room for the new ModelY to be launched soon. This shows that for those consumers who pursue the latest technology and have a higher rate of preservation, it may be a wiser decision to wait for the release of the new ModelY.

However, for those consumers who pursue cost performance and stability, the current ModelY is undoubtedly a good choice. Its intelligent configuration, endurance, and the standard three-electricity technology in the whole system are enough to make it stand out from competitors at the same price. Moreover, Tesla’s intelligent experience, especially the L2 assisted driving function of HW4.0, has made many car owners hooked up.

Of course, Tesla ModelY’s competitors are not to be outdone. Faced with Tesla’s price reduction strategy, Tucki Weilai Ideality and other brands have launched their own preferential policies, trying to get a slice of this year-end automobile market war. However, Tesla’s brand influence and ModelY’s product strength undoubtedly gave it more voice.

Finally, bring us back to the original question: Is it the best time to start ModelY? If you are a practical person who pays attention to cost performance, then the answer is yes. But if you are a technology fan, waiting for the release of the new ModelY may better meet your expectations. In any case, this round of preferential policies of Tesla ModelY has undoubtedly brought more changes and discussions to the automobile market at the end of the year.

In this ever-changing market, Tesla ModelY once again proved that it is the top player in the SUV market with its unique charm and preferential policies. For consumers, whether they are choosing existing styles or waiting for the new models to go on the market, ModelY is undoubtedly a noteworthy model. It must be understood that in this year-end automobile market competition, Tesla ModelY has won the love of countless consumers with its strength and sincerity.

CCTV News:At present, at the peak of Spring Festival travel rush, various measures have been introduced to help migrant workers return home.Warm the way home for migrant workers in Spring Festival travel rush.　

Every year, a large number of Shandong migrant workers return to their hometown by train K1282 in Guangzhou and Shenzhen. In order to let the passengers feel the warmth of their hometown in advance, the train staff decorated the dining car with Chinese knots, the word "Fu" and other items, and cooked Four Joy Meetballs and other Shandong dishes to let the passengers feel the warmth on the way back.

In order to create a warm Spring Festival travel rush, Luchuan County, Guangxi Province has launched a "warm way home" — — Luchuan migrant workers in Guangdong take the free bus to return home safely, so that Luchuan villagers who work outside the home can feel the warmth of home and ensure that they go home safely and smoothly for the New Year.

At present, at the peak of Spring Festival travel rush, Haigang District, Qinhuangdao City, Hebei Province is carrying out "‘ Qin ’ Such as a family, warm the way home ",providing 4 vehicles for 136 Heilongjiang and 44 Jilin returnees who work in Qin.be free of chargeBus, help them go home smoothly.

Wuxi, Jiangsu: Take many measures to cope with the freezing rain, snow and ice, and fully escort Spring Festival travel rush.

Affected by cold air, from February 6th to 7th, the temperature along the Yangtze River and southern Jiangsu will drop to minus 4 degrees, accompanied by rain and snow. The period affected by rain and snow coincided with the peak of Spring Festival travel rush’s return home, and various departments in Jiangsu took measures to ensure the smooth travel of the public during the Spring Festival.

Located in the overlapping section of Beijing-Shanghai Expressway and Shanghai-Chengdu Expressway, Jiangsu Wuxi Meicun Service Area is one of the busiest high-speed service areas in China during the Spring Festival. In order to cope with the impact of high passenger flow and rain and snow weather in Spring Festival travel rush, the service area has increased the charging guarantee for new energy vehicles, alleviating the possible problems such as the shortage of charging piles and the long queue for charging electric vehicles.

Li Ting, comprehensive room manager of Wuxi Meicun Service Area of Shanghai-Nanjing Expressway:The number of new energy vehicles has increased significantly, reaching 1700 vehicles per day.

Faced with the surge of new energy vehicle traffic, the local power supply department has taken various measures to increase the supply of charging facilities in the expressway service area and smooth the way home in Spring Festival travel rush.

Liu Hang, Deputy Director of Marketing Department of State Grid Wuxi Power Supply Company:In order to cope with the special weather this year, we have deployed a mobile energy storage charging vehicle and three mobile charging robots on the basis of the original eight fast charging piles. In addition, we have sent staff to be on duty 24 hours a day to guide the normal charging order during the charging peak period.

Jiangxi: Optimizing service measures to cope with low temperature rain and snow to ensure smooth roads

From the night of the 6th, rain and snow weather appeared in Jiujiang and Nanchang, Jiangxi Province, and the low-temperature rain, snow and freezing weather superimposed on the peak passenger flow in Spring Festival travel rush, which affected highways, national and provincial highways and rural roads to some extent. The local traffic police and emergency departments immediately acted to ensure the safety of people’s travel.

On the night of February 6, sleet appeared in some areas of Jiujiang in the north of Jiangxi, and the temperature of some expressway bridges dropped below 0℃, which was a hidden danger of icing. The high-speed traffic police in Jiangxi Province carried out several salt spraying operations on key bridge sections such as Jiujiang Bridge No.2, Poyang Lake Bridge No.1 and Bridge No.2 in the middle of the night, and isolated and channelized the key bridges to ensure that the traffic arteries did not freeze.

Affected by the low temperature, rain, snow and freezing weather, some sections of Taixi Highway, a provincial highway in Nanchang, are frozen and branches fall, which affects people’s traffic. The local traffic police department responded at the first time, sending more than 30 police officers to strengthen the patrol inspection of accident-prone road sections such as steep slopes, sharp turns, icy and slippery roads, remove fallen branches in time, and set up safety warning signs in conspicuous positions to close the icy road sections to ensure the safety of the people.

In the Ganzhou section of Daguang Expressway, the traffic flow northward increased significantly. Due to the continuous low temperature and rainy weather, the high-speed traffic police set up cones in front of intersections and hub ramps in various service areas to guide drivers and passengers to slow down and change lanes in advance. At the same time, the drone is used to shout, reminding the drivers and passengers to slow down. Remote pavement thermometers are installed in bridges, tunnels and other sections that are easy to freeze, so as to know the road temperature in real time.

Xinhua News Agency, Jinan, July 30thQuestion: How to deepen the "focus" of medical reform and make the medical service system from "having" to "excellent"?

Xinhua News Agency reporters Dong Ruifeng and Li Zhihao

China’s average life expectancy has increased to 78.2 years, and it has built the largest basic medical security network in the world, and its main health indicators are in the forefront of middle-and high-income countries … For more than a decade, China has continuously deepened the reform of the medical and health system, and made efforts to solve the problem of people’s difficulty and expensive medical treatment.

At present, what are the key tasks for deepening medical reform? In what areas are ordinary people expected to continue to enhance their sense of gain? At the 2023 National Experience Promotion Conference on Deepening Medical Reform and China Health Development Conference held in Jinan, Shandong Province from July 29th to 30th, many industry experts took stock of the list of previous medical reforms and looked forward to the next stage "road map".

Can there be more quality medical services at home?

Promoting "serious illness can be solved in this province, common diseases can be solved in cities and counties, and headaches and brain fever can be solved in towns and villages" is an important goal of deepening medical reform.

At present, China has identified 125 national regional medical center construction projects, and the medical service "highland" covers all provinces with weak resources. In 2021, the first batch of inter-provincial medical treatment for related specialties of national regional medical centers decreased by 9.3% compared with 2019.

"The national regional medical center has basically completed the planning and layout, and the next step is to promote the establishment of a management system and operational mechanism that is compatible with it." Zhu Hongbiao, a first-class inspector of the System Reform Department of the National Health and Wellness Commission, said.

Balanced layout of high-quality medical resources, the level of diagnosis and treatment at the grassroots level is also constantly improving. By the end of 2022, 87.71% of county hospitals in China had reached the basic standard of medical service capacity, and more than 30,000 township hospitals and community health service centers had reached the standard of service capacity.

Zhu Hongbiao said that in the future, we will continue to plan and build provincial regional medical centers, continuously improve the medical level of cities and counties, strengthen the capacity building of community and rural medical and health services, improve the system and mechanism for promoting graded diagnosis and treatment, and promote the inheritance and innovation of Chinese medicine.

Focusing on the long-term, it is necessary to deepen the reform of public hospitals oriented to public welfare and develop and strengthen the medical and health team in order to let the people enjoy more high-quality medical services at their doorstep.

Previously, the national public hospitals have cancelled the addition of drugs and medical consumables respectively. How to consolidate the public welfare foundation of public hospitals, at the same time, ensure the source of salary of public hospital staff and mobilize the enthusiasm of medical staff has become an urgent task. "The next step is to continuously consolidate and improve the new operating mechanism." Zhu Hongbiao said.

How to reduce the burden of individual self-payment of ordinary people?

According to the latest funding standard of basic medical insurance for urban and rural residents in 2023, the per capita financial subsidy standard is 640 yuan per person per year. Ten years ago, this standard was 280 yuan.

Statistics show that in recent years, China’s government health expenditure and social health expenditure have continued to increase, and the proportion of personal health expenditure in total health expenditure has continued to drop to 27.7%.

"But the money that some ordinary people actually took out of their pockets for medical treatment did not feel significantly reduced." Xu Shuqiang, dean of China Hospital Development Research Institute of Shanghai Jiaotong University, said that an important reason is that the expenses beyond the reimbursement scope of basic medical insurance are still heavy.

On the one hand, we must continue to solve the problem of expensive medical treatment, on the other hand, the price of medical services is low, and some medical institutions have losses. How to solve the problem?

Not long ago, with the consent of the State Council, the National Health and Wellness Commission and other six departments jointly issued "Key Tasks for Deepening the Reform of Medical and Health System in the Second Half of 2023", which clearly proposed to promote the orderly connection of multi-level medical security.

Shanghai launched customized commercial medical insurance "Huhuibao" based on the rule of "employees in this city voluntarily use the surplus funds of medical insurance personal accounts over the years to purchase commercial medical insurance". In 2021, the number of insured people reached 7.39 million, and by the end of 2022, the accumulated compensation was 790 million yuan, which became an effective supplement to basic medical insurance and helped people to "reduce the burden" of seeing a doctor.

On the basis of realizing the full coverage of long-term care insurance for employees, Shandong Province started the pilot project of long-term care insurance for residents in 2022. At present, the number of long-term care insurance participants in the province has reached 41.12 million, ranking first in the country, which better meets the long-term care needs of severely disabled people.

Xu Shuqiang believes that deepening medical reform should not only make people spend less and less money from their own pockets, but also promote the development of public hospitals. We can consider more reform measures in which medical expenses are paid by third parties. While continuing to play the basic role of medical insurance fund, we will actively promote the development of inclusive commercial medical insurance, commercial health insurance and long-term care insurance.

How to "use good medicine" and "supply good medicine"

At present, a new round of medical insurance drug list adjustment is under way, focusing on children’s drugs and drugs for rare diseases.

In recent years, with the implementation of many measures, such as medical insurance drug catalogue access negotiation and centralized quantity procurement, 341 new drugs have been included in the catalogue at suitable prices, and the average price of centralized drugs has been reduced by more than 50%, saving about 300 billion yuan.

According to Jin Chunlin, director of the Shanghai Health and Healthy Development Research Center, the preparatory work for centralized procurement is more adequate, the scheme design is more rigorous, and the drugs and medical consumables that benefit the people are more abundant.

According to the data of the National Medical Insurance Bureau, centralized purchasing not only promotes the price reduction of drugs, but also makes the proportion of original drugs and drugs evaluated by the consistency of generic quality and efficacy exceed 90%, and the accessibility of high-quality drugs is greatly improved.

Support drug R&D and innovation, regularly carry out centralized procurement of drugs and medical consumables, strengthen drug supply guarantee and quality supervision … Focus on reform and innovation in the medical field, and a series of key tasks will be continuously promoted in the second half of this year to ensure "good supply of drugs" and "good use of drugs".

The relevant person in charge of the Department of Restructuring of the National Health and Wellness Commission said that this year, all provinces will be instructed to carry out centralized procurement of drugs and consumables at least once, and it is required to achieve a total of 450 drugs collected at the national and provincial levels before the end of the year.

In addition, it is understood that promoting the coordination and integration of medical care and prevention, promoting the reform of disease prevention and control system, and improving the capacity of public health services will also be important contents of deepening medical reform in the next stage, and a series of guiding documents are expected to be issued this year.

　　Cctv newsAccording to the website of the National Bureau of Statistics, according to preliminary accounting, the GDP in the first three quarters was 59,328.8 billion yuan, up 6.9% year-on-year at comparable prices, and the growth rate was the same as that in the first half of the year, 0.2 percentage points faster than that in the same period of the previous year. In terms of industries, the added value of the primary industry was 4,122.9 billion yuan, a year-on-year increase of 3.7%; The added value of the secondary industry was 23,810.9 billion yuan, an increase of 6.3%; The added value of the tertiary industry was 31,395.1 billion yuan, an increase of 7.8%. In the third quarter, the gross domestic product increased by 6.8% year-on-year, and the economy operated in the range of 6.7-6.9% for nine consecutive quarters, maintaining medium and high-speed growth.

　　First, the grain production situation is good, and the animal husbandry is growing steadily.

　　The total output of summer grain in China was 140.52 million tons, an increase of 1.31 million tons or 0.9% over the previous year. The total output of early rice was 31.74 million tons, a decrease of 1.04 million tons or 3.2% over the previous year. Autumn grain is expected to get a good harvest. In the first three quarters, the output of pork, cattle, sheep and poultry was 58.77 million tons, up 0.8% year-on-year, of which the output of pork was 37.17 million tons, up 0.7%. The number of live pigs was 427.97 million, a year-on-year decrease of 0.8%; 482.24 million pigs were slaughtered, an increase of 0.6%.

　　II. Accelerating the development of industrial production and improving the efficiency of structural optimization.

　　In the first three quarters, the added value of industrial enterprises above designated size increased by 6.7% year-on-year, and the growth rate was 0.7 percentage points faster than that of the same period of last year. In terms of economic types, the added value of state-owned holding enterprises increased by 6.8%, collective enterprises increased by 0.3%, joint-stock enterprises increased by 6.8%, and foreign-invested enterprises from Hong Kong, Macao and Taiwan increased by 7.1%. In terms of three categories, the added value of mining industry decreased by 1.6% year-on-year, manufacturing industry increased by 7.3%, and electricity, heat, gas and water production and supply industries increased by 8.4%. In the first three quarters, the added value of high-tech manufacturing and equipment manufacturing increased by 13.4% and 11.6% respectively, which was 6.7 and 4.9 percentage points faster than that of industries above designated size. In the first three quarters, the production and sales rate of industrial enterprises above designated size reached 97.8%. In September, the added value of industrial enterprises above designated size increased by 6.6% year-on-year, 0.6 percentage points higher than that of the previous month and 0.56% higher than that of the previous month. In September, the purchasing managers’ index of manufacturing industry was 52.4%, 0.7 percentage points higher than last month, reaching the highest point since May 2012.

　　From January to August, the total profits of industrial enterprises above designated size nationwide reached 4,921.4 billion yuan, a year-on-year increase of 21.6%; The profit rate of main business income of industrial enterprises above designated size was 6.13%, an increase of 0.45 percentage points over the same period of last year. In August, the total profits of industrial enterprises above designated size increased by 24% year-on-year, 7.5 percentage points faster than last month.

　　Third, the service industry maintained rapid development, and the business activity index continued to improve.

　　In the first three quarters, the national service industry production index increased by 8.3% year-on-year, and the growth rate was 0.2 percentage points faster than the same period of last year. Among them, transportation, warehousing and postal services, information transmission, software and information technology services, leasing and business services grew rapidly. In September, the national service industry production index increased by 8.3% year-on-year, and the growth rate was the same as last month, 0.2 percentage points faster than the same month of last year. From January to August, the operating income of service enterprises above designated size increased by 13.5% year-on-year, 3.4 percentage points faster than the same period of last year; The operating profit of service enterprises above designated size increased by 22.8% year-on-year, accelerating by 22.4 percentage points year-on-year.

　　In September, the business activity index of service industry was 54.4%, 1.8 percentage points higher than that of last month and 2.1 percentage points higher than that of the same month of last year. The business activity indices of the wholesale industry, telecommunications, broadcasting, television and satellite transmission services, Internet and software information technology services, monetary and financial services, capital market services, insurance and other industries are all in the high boom zone of more than 60.0%. The new order index of service industry was 51.5%, and the expected index of business activities was 60.8%, which were 1.2 and 0.7 percentage points higher than that of last month respectively.

　　Four, the investment in fixed assets is stable and slightly slow, and the investment structure is adjusted and optimized.

　　In the first three quarters, the national investment in fixed assets (excluding farmers) was 458.478 billion yuan, up 7.5% year-on-year, and the growth rate dropped by 0.7 percentage points over the same period of last year. Among them, the state-owned holding investment was 16,816.4 billion yuan, an increase of 11.0%; Private investment was 27,752 billion yuan, up 6.0%, accounting for 60.5% of the total investment. By industry, the investment in the primary industry was 1,497.3 billion yuan, an increase of 11.8%; The investment in the secondary industry was 17,178.7 billion yuan, up by 2.6%, of which the investment in manufacturing industry was 14,081.9 billion yuan, up by 4.2%. Investment in the tertiary industry was 27,171.8 billion yuan, an increase of 10.5%. Infrastructure investment was 9,965.2 billion yuan, up by 19.8%, 0.4 percentage points faster than the same period of last year. Investment in high-end manufacturing and technological transformation of enterprises grew rapidly, while investment in high-energy-consuming industries slowed down. In the first three quarters, investment in high-tech manufacturing, equipment manufacturing and technological transformation of manufacturing increased by 18.4%, 8.3% and 12.1% respectively, while investment in high-energy-consuming manufacturing decreased by 1.9%. The investment in fixed assets reached 45.7 trillion yuan, up 3.3% year-on-year, and the growth rate was 1.9 percentage points faster than that in the first half of the year. The planned total investment of newly started projects is 37,634.7 billion yuan, up 2.4% year-on-year. From the ring comparison, investment in fixed assets (excluding farmers) increased by 0.56% in September compared with the previous month.

　　V. Investment in real estate development grew steadily, and the area of commercial housing for sale continued to decrease.

　　In the first three quarters, the national real estate development investment was 8,064.4 billion yuan, up 8.1% year-on-year, and the growth rate was 2.3 percentage points faster than that of the same period of last year. Among them, residential investment increased by 10.4%. The newly started housing area was 1,310.33 million square meters, up 6.8% year-on-year, of which the newly started residential area increased by 11.1%. The national commercial housing sales area was 1,160.06 million square meters, up by 10.3%, of which the residential sales area increased by 7.6%. The sales volume of commercial housing nationwide was 9,190.4 billion yuan, up by 14.6%, of which residential sales increased by 11.4%. The land acquisition area of real estate development enterprises was 167.33 million square meters, a year-on-year increase of 12.2%. At the end of September, the area of commercial housing for sale nationwide was 611.4 million square meters, a decrease of 12.12 million square meters from the end of last month. In the first three quarters, real estate development enterprises received 11,309.5 billion yuan in funds, up 8.0% year-on-year.

　　Six, the market sales continued to grow rapidly, and the online retail growth was strong.

　　In the first three quarters, the total retail sales of social consumer goods was 26,317.8 billion yuan, up 10.4% year-on-year, and the growth rate was the same as that of the same period of last year. Among them, the retail sales of consumer goods above designated size was 11,775.1 billion yuan, an increase of 8.5%. According to the location of business units, the retail sales of urban consumer goods was 22,559.2 billion yuan, an increase of 10.1%; The retail sales of rural consumer goods reached 3,758.6 billion yuan, up by 12.1%. According to consumption types, catering revenue was 2,842.7 billion yuan, up by 11.0%; Retail sales of commodities reached 23,475.1 billion yuan, up by 10.3%, of which retail sales of commodities above designated size reached 11,071.7 billion yuan, up by 8.5%. Sales of consumption-upgraded goods grew rapidly, with sports and entertainment products increasing by 17.4%, cosmetics by 12.1% and building and decoration materials by 12.6%. In September, the total retail sales of social consumer goods increased by 10.3% year-on-year, 0.2 percentage points faster than the previous month and 0.90% higher than the previous month.

　　In the first three quarters, the national online retail sales reached 4,878.7 billion yuan, up 34.2% year-on-year, 8.1 percentage points faster than the same period of last year. Among them, the online retail sales of physical goods was 3,682.6 billion yuan, up by 29.1%, accounting for 14.0% of the total retail sales of social consumer goods, up by 2.3 percentage points year-on-year; Online retail sales of non-physical goods reached 1,196.1 billion yuan, an increase of 52.8%.

　　Seven, the rapid growth of imports and exports, foreign trade structure continued to improve.

　　In the first three quarters, the total import and export volume was 20,293 billion yuan, a year-on-year increase of 16.6%. Among them, the export was 11.163 billion yuan, an increase of 12.4%; Imports reached 9,129.9 billion yuan, up by 22.3%. Import and export balance, with a surplus of 2,033.1 billion yuan. The proportion of general trade import and export increased. In the first three quarters, the import and export of general trade increased by 18.1%, accounting for 56.6% of the total import and export, an increase of 0.7 percentage points over the same period of last year. Mechanical and electrical products are still the main export force. In the first three quarters, the export of mechanical and electrical products increased by 13.0%, accounting for 57.5% of the total export. Imports and exports with some countries along the Belt and Road increased rapidly. In the first three quarters, China’s imports and exports to Russia, Poland and Kazakhstan increased by 27.7%, 24.8% and 41.1% respectively. In September, the total import and export volume was 2,458.9 billion yuan, a year-on-year increase of 13.6%. Among them, exports were 1,326 billion yuan, up 9.0%; Imports reached 1,133 billion yuan, up by 19.5%.

　　In the first three quarters, industrial enterprises above designated size achieved a export delivery value of 9,427 billion yuan, a year-on-year increase of 10.7%. In September, industrial enterprises above designated size realized export delivery value of 1,190.6 billion yuan, an increase of 9.8%.

　　Eight, consumer prices rose moderately, and industrial prices fluctuated.

　　In the first three quarters, the national consumer price rose by 1.5% year on year. Among them, cities rose by 1.6% and rural areas rose by 1.1%. By category, the prices of food, tobacco and alcohol decreased by 0.6%, clothing by 1.3%, housing by 2.5%, daily necessities and services by 0.9%, transportation and communication by 1.1%, education, culture and entertainment by 2.5%, medical care by 5.7% and other goods and services by 2.6%. Among the prices of food, tobacco and alcohol, the price of grain increased by 1.5%, the price of pork decreased by 8.7%, and the price of fresh vegetables decreased by 8.8%. In September, the national consumer price rose by 1.6% year-on-year, down 0.2 percentage points from the previous month and up 0.5% from the previous month.

　　In the first three quarters, the ex-factory price of industrial producers nationwide rose by 6.5% year-on-year. In September, the ex-factory price of industrial producers nationwide rose by 6.9% year-on-year, with an increase of 0.6 percentage points from the previous month and 1.0% from the previous month. In the first three quarters, the purchase price of industrial producers nationwide rose by 8.4% year-on-year; In September, it rose by 8.5% year-on-year and 1.2% quarter-on-quarter.

　　Nine, the income growth of residents accelerated, and the income gap between urban and rural areas continued to narrow.

　　In the first three quarters, the per capita disposable income of national residents was 19,342 yuan, a nominal increase of 9.1% year-on-year; After deducting the price factor, it actually increased by 7.5%, and the growth rate was 1.2 percentage points faster than the same period of last year. According to the place of permanent residence, the per capita disposable income of urban residents is 27,430 yuan, a real increase of 6.6% after deducting the price factor; The per capita disposable income of rural residents was 9778 yuan, a real increase of 7.5% after deducting the price factor. The per capita income difference between urban and rural residents was 2.81, 0.01 less than the same period of last year. The median per capita disposable income of the national residents was 16,780 yuan, a nominal increase of 7.4% year-on-year. The per capita consumption expenditure of the national residents was 13,162 yuan, a nominal increase of 7.5% year-on-year, and a real increase of 5.9% after deducting the price factor. At the end of the third quarter, the total number of rural laborers who went out to work was 179.69 million, an increase of 3.2 million or 1.8% over the same period of the previous year. In the third quarter, the average monthly income of migrant rural laborers was 3,459 yuan, an increase of 7.0%.

　　X. New progress has been made in structural reform on the supply side, and new steps have been taken in transformation and upgrading.

　　"Three to one, one drop and one supplement" is progressing smoothly. De-capacity was accelerated. In the first three quarters, the national industrial capacity utilization rate was 76.6%, an increase of 3.5 percentage points over the same period of last year. The effect of destocking was outstanding. At the end of September, the area for sale of commercial housing decreased by 12.2% year-on-year. The effect of deleveraging and cost reduction continued to appear. At the end of August, the asset-liability ratio of industrial enterprises above designated size was 55.7%, down 0.7 percentage points from the same period of last year. From January to August, the cost per 100 yuan of main business income of industrial enterprises above designated size was 85.68 yuan, a decrease of 0.12 yuan over the same period of last year. Investment in short-board areas grew rapidly. In the first three quarters, investment in ecological protection and environmental management, public facilities management and agriculture increased by 25.0%, 23.7% and 16.2% respectively, which was 17.5, 16.2 and 8.7 percentage points faster than the total investment.

　　The leading role of the service industry has been strengthened. In the first three quarters, the added value of the tertiary industry accounted for 52.9% of the GDP, which was 12.8 percentage points higher than that of the secondary industry. Consumption has become the main driving force of economic growth, and the contribution rate of final consumption expenditure to GDP growth in the first three quarters was 64.5%, an increase of 2.8 percentage points over the same period of last year. New kinetic energy accelerated its growth. In the first three quarters, the added value of industrial strategic emerging industries increased by 11.3% year-on-year, 4.6 percentage points faster than that of industries above designated size. Green development progressed steadily, and energy consumption per unit of GDP decreased by 3.8% year-on-year in the first three quarters.

　　Generally speaking, in the first three quarters, the national economy continued to develop steadily and steadily, and the favorable conditions to support the economy to maintain medium and high-speed growth and move towards the middle and high-end level continued to accumulate and increase, and the inclusiveness and sense of gain of development were significantly enhanced, laying a solid foundation for better achieving the expected goals of economic development throughout the year. However, we should also see that the international environment is still complicated and changeable, and the domestic economy is still in the period of structural adjustment, and the foundation for sustained improvement needs to be further consolidated. In the next stage, under the guidance of the spirit of the 19th National Congress of the Communist Party of China, we should thoroughly implement the decision-making arrangements of the CPC Central Committee and the State Council, pay close attention to policy implementation and reform, and comprehensively do a good job in stabilizing growth, promoting reform, restructuring, benefiting people’s livelihood and preventing risks, so as to promote sustained and healthy economic development and social harmony and stability.

　　China News Service, Haikou, December 21 ST Title: Hainan real estate market in 2019: New opportunities are bred in the change.

　　China News Service reporter Wang Ziqian

　　2019 is the second year of Hainan’s implementation of the "global purchase restriction" policy. The real estate market is running steadily and declining, and the economy’s dependence on real estate is gradually decreasing.

　　In April 2018, Hainan issued a series of control policies to strictly control real estate with the determination of "a strong man breaks his wrist". According to official data, after experiencing a sharp decline in 2018, the real estate market continued its downward trend in 2019: real estate development investment, housing sales area and housing sales in the first 11 months decreased by 25.1%, 44.1% and 40.7% year-on-year.

　　The market chill continues, and Hainan real estate enterprises generally take the defensive. Luo Hao, general manager of Hainan R&F Strategic Development Center, said that the large housing enterprises currently investing in Qiong have generally contracted strategically, and some enterprises have withdrawn from the market.

　　Under the background of the decline of real estate industry, Hainan is forming new development momentum such as exhibition, health care and finance, and its economic transformation is difficult but effective. According to the analysis of the General Office of Hainan Provincial Bureau of Statistics, the cumulative growth rate of real estate investment in South Africa in the first 11 months turned from negative to positive, with a growth rate of 8.6%.

　　The household registration and talent policy introduced in Hainan this year triggered speculation on the liberalization of purchase restrictions. Wang Yiwu, dean of Hainan Institute of Modern Management and a professor at Hainan University, said that the policy is aimed at introducing talents for building free trade zones (ports), which still has a high threshold for speculative property buyers. "It will stimulate the market to some extent in the short term, but it will not play a decisive role".

　　The property market is generally cold, but there are differences in performance in different regions. Haikou city, which is mainly in need, rose against the market. In the first 11 months, sales rose by 35.5% instead of falling, and sales in Sanya city, which represents tourist residential real estate, plummeted by 51.3%.

　　Since the second half of this year, Hainan Province has successively introduced household registration and talent policies, and Haikou City has also opened the ceiling of housing prices. At the end of the year, housing enterprises promoted price-for-quantity, releasing some rigid demand. Liang Chunfen, a property buyer, said that a property she pre-purchased was snapped up in less than ten minutes when it opened in December. "Several friends around me are ready to buy a house, and the current market price is stable and discounted."

　　Hainan’s land market is hotter than the property market, and it opened in the fourth quarter. The local media published land transfer information intensively, but the land type has changed from residential land to industrial land and business office land. "This trend is the process of building a free trade zone (port) to be residential, and it is the peak time when land use begins to enter industrial and commercial office land." Wang Lu, secretary general of Haikou Real Estate Association, said.

　　Another noteworthy thing is that a number of off-island real estate enterprises entered Hainan for the first time against the market. According to the industry, this shows that enterprises have good expectations for the free trade zone (Hong Kong) and believe that the Hainan market is still a "hot land".

　　The year 2020 is the opening year of the construction of Hainan Free Trade Port. Shen Xiaoming, governor of Hainan, once said that by the end of the first quarter of 2020, the downward pressure on the economy caused by real estate adjustment can be basically released, and Hainan’s economy will enter a benign and rapid development track.

　　Wang Zhi, director of the real estate market supervision department of the Housing and Urban-Rural Development Department of Hainan Province, said that Hainan will continue to maintain the continuity and stability of real estate control policies, and encourage the development of various shared residential products such as timeshare, online leasing and house sharing.

　　Luo Hao pointed out that the sales of commercial housing in Hainan will continue to shrink next year, but for housing enterprises, commercial activities will increase, and the housing demand of newly introduced talents will become new opportunities in the market. Wang Yiwu said that housing enterprises should actively shift from simple real estate developers to real estate suppliers, operators and social service providers.

　　For the changing Hainan property market, the new market environment will test the capabilities of both enterprises and the government. Wang Lu said that for enterprises, it is necessary to realize the transformation from traditional residential development to the development and operation of business offices and industrial parks; For the government, "commercial property management means changing from the needs of people in the past to the needs of industries, which will put forward higher requirements for Hainan’s industrial development". (End)